Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22. doi: 10.1016/s0960-894x(00)00273-0.

Abstract

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

MeSH terms

  • Humans
  • Kinetics
  • Models, Structural
  • Molecular Conformation
  • Prostaglandins / chemical synthesis*
  • Prostaglandins / chemistry
  • Prostaglandins / metabolism*
  • Receptors, Prostaglandin / metabolism*
  • Structure-Activity Relationship

Substances

  • Prostaglandins
  • Receptors, Prostaglandin
  • prostaglandin F2alpha receptor